Buspirone Withdrawal and Tapering Help

Other Names for Buspirone Include:  (Buspar, Ansiced, Ansial, Anxiron, Axoren, BuSpar, Buspimen, Buspinol, Buspisal, Narol, Spitomin, Sorbon)

Buspirone was first identified by a research team at Mead Johnson in 1972 but not patented until 1975. FDA approved was obtained in 1986 and when the patent expired in 2001, Buspirone became available as a generic drug. Buspirone is approved for the treatment of anxiety disorders in the United States, Australia and the United Kingdom and indicated only for short-term treatment and is not effective in persons with severe anxiety or panic disorders.

Buspirone is thought to work on the 5-HTIA receptor; a subtype of the Serotonin receptor but the exact mode of action is not known. Buspar has moderate affinity for the brain Dopamine receptors and some studies suggest an indirect effect on other neurotransmitter systems. This action increases the concentration of noradrenaline and dopamine while causing suppression of serotonin and acetylcholine. This dual effect is believed to lead to relief from anxiety but also the side effect profile that includes feeling faint, uneven heartbeats, depression, mood swings, unusual thoughts, restlessness, nausea, insomnia, poor concentration and lack of coordination. Approximately 10% of patients discontinued clinical trials  due to an adverse event.

Dangerously high blood pressure has resulted from the combination of Buspirone and MAO Inhibitors. Because of this Buspirone should never be taken in combination with MAO Inhibitors or with Turmeric that has a similar action. After stopping Buspirone it is important to wait at least 10 days prior to ingesting MAO Inhibitors or Turmeric. Grapefruit consumption can also increase the effects of Buspirone.

While studies have shown that Buspirone does not have a discontinuation syndrome, yet many patients report insomnia, anxiety and increased depression if their dosage is reduced too rapidly. Dr. Peter Breggin states that like all minor tranquilizers, Buspar is habit forming, addictive and can cause life-threatening neurological reactions. The side effects are similar to benzodiazepines and abrupt withdrawal can cause the same rebound insomnia, depression and anxiety.

Our nonprofit can assist you to taper Buspirone with slow titration schedules combined with calming nutraceuticals (all-natural) to ease Buspirone Withdrawal Symptoms.

If you feel trapped by medications, please know that there is hope.  I am now free of the grip of Ativan and Klonopin.  You can do this! - Paul M., California (Ativan, Klonopin)