Fluorquinolone (Quinolone) Reactions
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Fluoroquinolones are antibiotics used to treat many strains of bacterial pathogens. It is also considered a chemotherapeutic antibiotic and a 2005 study from Italy found that among more than 50 types of drugs, Fluroquinolones were involved in the largest number of serious problems and accounted for 11% of all adverse events.
Fluoroquinolones works by interfering with bacterial DNA, preventing it from replicating. However, lawsuits contend that Cipro also attacks healthy DNA, accounting for its widespread side effect profile. Many refer to the horrible reactions as a “Fluoroquinolone toxicity syndrome.” Fluoroquinolones are extremely powerful antibiotics and were originally developed for serious or deadly infections that did not respond to first-line antibiotics. Today Fluoroquinolones are being used to common bacterial infections in spite of the dangerous and potentially deadly side effects.
Over 20 million outpatient prescriptions were written for Cipro in 2010, making it the 5th most commonly prescribed antibacterial in the United States. In 2011 the FDA added two black box warnings for Cipro relating to spontaneous tendon ruptures, worsening muscle weakness and potentially life-threatening breathing problems. Neurotoxicity was on the first side effects reported with Floroquinolones and it is estimated that up to 1/3 of patients will experience some sort of psychiatric side effect including anxiety, personality changes or confusion.
Multiple studies have shown that an adverse reaction to Fluoroquinolone induces oxidative stress and causes substantial Glutathione Depletion (body’s master antioxidant). The oxidative stress was correlated with Glutathione depletion after 72 hours of exposure to Fluoroquinolones. The hypothesis is that Glutathione falls so rapidly that any other intracellular antioxidant loses their ability to control the overproduction of Reactive Oxygen Species (ROS), which are chemically reactive and cause damage to the cells. This damaging effect is greatest 5 days after exposure to ciprofloxacin and levofloxacin therapy, both are Fluoroquinolones.
A study conducted in 2011 by the Department of Pharmacology and Toxicology in Hyderabad, India confirmed that Fluoroquinolones caused enormous oxidative stress and a subsequent depletion of Glutathione, the body’s master antioxidant.
Additionally, Flouroquinolones, like all antibiotics, will destroy the normal intestinal flora and can lead to decreased production of B vitamins and Vitamin K. Therefore it is essential to replenish the healthy gut bacteria with probiotics. For help with Fluoroquinolone reactions call toll free 866.605.2333 or send us a inquiry.
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Fluoroquinolone Side Effects May Include:
Irritation of the Stomach or Intestines, High Blood Pressure, Drug or Chemical-Induced Sensitivity to Sunlight, Rash, Fluid Retention in the Legs, Feet, Arms or Hands, Chest Pain, Feel Like Throwing Up, Diarrhea, Stomach Cramps, toxic psychosis, retinal detachment, tendon rupture, seizures, heart arrhythmias, muscle damage, abnormal liver function, kidney damage, toxic effect on Brain or Spinal Cord Function, Restlessness, Yellowing of skin or eyes from liver issues, discolored spots on skin, migraines, neuropathy, double vision, pancreatitis, Angina, Paraxysmal supraventricular tachycardia, rapid ventricular heartbeat, Atrial fibrillation, Slow heartbeat, Abnormally lowe blood ressure, widenting of blood pressure, widenting of blood vessels, asthma, inflammation in lungs, painful/swollen mouth or tongue, acute liver failure, hepatitis, interstitial Nephritis, acute kidney disease, bloody urine, severe bloody diarrhea, inflammation of skin, hives, joint pain, tendon issues such as rupture or inflammation, hallucination, faint feeling, involuntary quivering, numbness, water retention, trouble breathing, difficulty swallowing, high amout of uric acid in the blood, high blood sugar, feeling weak, high amount of triglyceride in the blood, high fat content in blood, anemia, decreased blood platelets, deficiency of granulocytes, decreased white blood cells, confusion, nightmares, depression, lazy eye, ringing in the ears, dry mouth, discolored tongue, burning stomach, indigestion, itching, fry skin, arthritis, backache, muscle pain, drowsiness, chronic insomnia, excessive sweating, pain, chills, problems with taste or smell, coordination issues, loss of appetite, excessive thirst, head pain, nosebleed, swollen lymph nodes, thrush, yeast infection, gas, urination problems, anxiousness
REFERENCES:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249743/http://jpet.aspetjournals.org/content/308/1/394.ful
http://www.ncbi.nlm.nih.gov/pubmed/15478945
http://www.ncbi.nlm.nih.gov/pubmed/22092852
http://www.revmedvet.com/2001/RMV152_235_238.pdf
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